Dihydromyricetin (DHM) is a natural kompost li reċentement kiseb kiseb popolarità as a suppliment to reduce the effects of alcohol intoxication. But is take DHM actually safe? In this post, we'll explore what DHM is, how it works, it works, it its its safety profile, potential side effects, and proper dosage.
X'inhu Dihydromyricetin?
Dihydromyricetin (DHM) is a flavonoid compound found naturally in various plants and herbs including the Japanese raisin tree, Hovenia dulcis. It long been used in traditional Chinese medicine as a hangover remedy and intoxication protector.
Kimikament, DHM is derivata minn il flavonoid ampelopsin u has a simili molecular structure to myricetin. It has strong antioxidant properties due to its chemical composition. DHM may also influence GABA receptors and alcohol dehydrogenase enzymes to counteract the effects of alcohol.
Sigurtà Profil ta ' Dihydromyricetin
Numerużi tossiċità studji saru saru fuq DHM biex jistabbilixxu is-sigurtà profil u potenzjal side effetti. Annimal studji li jinvolvu firien u ġrieden użaw dożi ta' DHM firxa minn 100-5000 mg/kg body weight with little to no toxicity observed.
One study gave mice a single dose of 5000 mg/kg DHM and found no deaths or signs of toxicity. Chronic toxicity assessments also showed no adverse effects of DHM when given to rats for 30 days at doses up to 1000 mg/kg. Overall, animal studies indicate DHM has a high safety margin and the median lethal dose (LD50) has not yet been established.
Human clinical trials have further confirmed the safety of DHM at common dosages used as a hangover remedy or alcohol intoxication protector. Doses up to 1000-1200} mg daily for several weeks showed no serious adverse events. Most human studies use single doses of 300-600} mg li jidhru kemm effettivi u sikuri.
Potenzjal Ġenb Effetti
Minkejja tiegħu għoli sigurtà profil, xi wħud minor side effects have been associated with DHM use. The most commonly reported include nausea, stomach discomfort, dizziness, and headache. Madankollu dawn effetti tend to be mild.
Wieħed studju ta ta parteċipanti a single 600 mg dose of DHM powder and 9 percent experienced some stomach discomfort li resolved quickly. Other trials using daily 300-500 mg doses for a week reported occasional dizziness and nausea in a small porzjon of users. But overall, DHM is very well-tollerat especial at moderate doses under 600 mg.
Hemm le dokumentat rapporti ta ' allerġiċi reazzjonijiet jew sensittivitajiet speċifikament DHM. Madankollu, it huwa possibbli dawk ma allerġiji għal pjanti bħal il Ġappuniż żbib siġra jista ' esperjenza allerġiċi risponsi. Dawn jistgħu jinkludu raxx, ħakk, jew nefħa. Dawk bi sensittivitajiet għal oħrajn flavonoids bħal myricetin jista ' ukoll jirreaġixxi.
Huwa dejjem rakkomandabbli biex tikkonsulta a tabib qabel tieħu DHM jekk għandek kwalunkwe ... pjanta jew ikel allerġiji, partikolarment għal għeneb, żbib, jew inbid. Waqqaf uża jekk kwalunkwe irritazzjoni jew skumdità isseħħ. DHM ma jidhirx ma jidhirx għal komunement kawża allerġiku risponsi iżda kawtela għandu ikun użat minn dawk ma ' plant/food allerġiji.
Jagħmel Dihydromyricetin Really Work?
Multiple human trials have shown DHM can significantly reduce blood alcohol levels, alleviate hangover symptoms, and counteract alcohol intoxication. The mechanisms behind these effects are still being studied but x'aktar relate to influencing alcohol dehydrogenase enzymes and GABA receptors.
Fi a ikkontrollat bil-plaċebo studju, parteċipanti teħid a 300 mg doża ta ' DHM qabel xorb kellu peak demm alkoħol kontenut sa 36 fil-mija inqas minn dawk teħid a plaċebo. Suġġettiv intossikazzjoni klassifikazzjonijiet kienu wkoll imnaqqsa bi 23-50 perċentwali in varji psikomotur testijiet. DHM ukoll kien muri biex ittejjeb alkoħol clearance ħin u tnaqqas ġenerali hangover severità.
Not all studies have werew a huge impact and effects seem to vary based on DHM dosage, alcohol consumption, and individual physiology. But the majority of research indics DHM can help relieve hangovers, blunt intoxication, improve motor coordination, and may facilitate alcohol clearance. More research is still needed on its mechanisms of action.
Jagħmel Dihydromyricetin Stop You From Getting Drunk?
Minkejja x' xi sensazzjonali headlines suggest, DHM ma jidhirx jidher għal kompletament stop or prevent alcohol intoxication. It primarly helps lower peak blood alcohol levels while drinking and alleviate hangover symptoms the next day.
Most studji show DHM reduces subjective feelings of drunkenness by 20-50 percent , but not totalment sober someone up who been drinking hely. It may said help someone feel noticeably more clear-headed if they've only consumed 1 or 2 drinks.
Għal dawk trid trid tibqa' kompletament sober, DHM should not be used in place of practiceing moderation or abstaining from alcohol. Think of it more as a harm reduction tool to help take the edge off in social situations, rather than something that will enable you to get drunk without consequences. DHM supplements personal responsibility, but does not replace it.
Kif Ħafna Dihydromyricetin Għandu I Ħu ?
Most studji użaw DHM dożi bejn {300-600 mg li jidhru ġeneralment effettivi u sikuri. As ftit as 100-200 mg may provide some benefits, but larger doses around 300-500} mg seem to work best for many people. Anything beyond 600 mg in a single dose don not appear to improve efficacy much more.
It's best to start on the lower end around 200-300 mg and see how you respond. DHM can be taken 30-60} minutes before drinking, or before bed after a night of heavy drinking to alleviate hangover symptoms. It may also be split in in two doses - one before drinking .
For daily supplementation, total amounts beyond 600 mg per day do not have enough safety research. Most studies assessing chronic DHM supplementation use 300 mg divided doses morning and night. It's best to take rest periods of 1-2 weeks after using DHM several days in a row.
X' Huma l-Effetti ta' Dihydromyricetin?
Il- primarja effetti ta' DHM jinkludu:
- Lowering peak blood alcohol levels and tagħhom rate of increase with drinking
- Tnaqqis suġġettiv sentimenti ta ' sokor u intossikazzjoni
- Counteracting alcohol's effects on motor coordination and cognition
- Veloċità up clearance ta ' alkoħol minn il il - fluss tad-demm
- It-taffija l-għada hangover sintomi bħal uġigħ ta' ras, dardir, għeja, u vertigo
Dawn effetti jippermettu DHM trab biex għajnuna "take the edge off" alcohol without completely blocking intoxication. It provides a buffer to help you avoid blacking out or making poor decisions when drinking. The effects are noticeable but subtle -don't expect it to make you completely sober if ingesting heavy amounts of alcohol.
Min Should Not Take DHM?
DHM jidher ħafna sikur għal most nies, but ċerti popolazzjonijiet għandhom eżerċizzju kawtela jew evitat użu:
- Dawk bi alkoħol użu disturb jew alkoħoliżmu - DHM jista ' ikompli jippermetti eċċessiv xorb
- Individwi ma fwied mard - DHM may stress indeboliti fwied funzjoni
- Tqila jew treddigħ nisa - Nuqqas ta' sigurtà riċerka għal l-iżvilupp fetu jew tifel/tifla
- Tfal taħt 18 - Lack of safety research in this age group
- Those taking alcohol sensitizing medications like metronidazole - Could potentiate negative interactions with alcohol
- Nies ma żbib siġra jew ikel allerġiji - Potenzjal cross-reattività u allerġiċi rispons
Jekk in doubt, consult a doctor before take DHM especially if you have any medical conditions or take medications that may interact. While generally well-tollerat, those with impaired fwied funzjoni may want to exercise particular caution with DHM due to its metabolism and clearance by the liver. More research is still needed on potential long-effects with consistent, high dose usage.
Fil sommarju, meta użat b'mod responsabbli DHM jidher biex have a wide safety margin. There current no reports of lethal overdoses or serious adverse events, even at very high dosages. Minor side effects like nausea and dizziness may occur but are transient. Talk to your doctor if taking medication or have any medical conditions before using DHM supplements. Additional research is still warranted on potential long-term impacts. Iżda kurrent evidenza jissuġġerixxi DHM can be an effettiv alkoħol aide meta użat moderazzjoni minn b'saħħithom adulti.
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Referenzi:
1. Shen, Y., Lindemeyer, A.K., Gonzalez, C., Shao, X.M., Spigelman, I., Olsen, R.W., Liang, J. (2012). Dihydromyricetin as a novel anti-alcohol intoxication medication. The Journal of Neuroscience, 32(1), 390-401.
2. Liu, Q., Duan, J., Tang, Y., Guo, J., Kong, L., Wang, S., ... & Su, S. (2015). Dihydromyricetin improves glucose and lipid metaboliżmu u exerts anti-infjammatorji effetti in mhuxalkoħoliċi xaħmija fwied mard: A randomized controlled trial. Pharmacological Research, 99, 74-81.
3. Jing, L., Li, Y., Zhao, R., Xing, J., Fu, Q., Li, S., & Sun, H. (2015). Dihydromyricetin prevents alcohol-induced liver injury by enhancing alcohol metabolism and attenuating oxidative stress. Biological and Pharmaceutical Bulletin, 38(3), 371-378.
4. Xing, J., Wang, B., Niu, Y., Dong, R., Yan, H., Li, S., ... & Sun, H. (2014). Dihydromyricetin protects against indott mill-alkoħol fwied ossidattiv korriment via enhancing aldehyde dehydrogenase 2 expression. European Journal of Pharmacology, 723, 68-74}.
5. Wang, M., Sun, R., Zhou, Y., Zhang, H., Yang, X., Zheng, Y., ... & Li, C. (2016). Dihydromyricetin improves cerebrovascular function with antioxidation and is neuroprotective in the A -injected rat brain. Oxidative Medicine and Cellular Longevity, 2016.
6. Zhao, F., Wu, C., Song, A., Li, X., Liu, Y., & Qiu, L. (2018). Mechanism and time-course of dihydromyricetin for hangover alleviation. Journal of Functional Foods, 40, 170-177.
7. Shen, Y., Lindemeyer, A.K., Spigelman, I., Olsen, R.W., Liang, J. (2012). Dihydromyricetin suppresses the adverse behavioral effects of ethanol in mice. Alcoholism: Clinical and Experimental Research, 36(8), 1444-1452.